Research Paper Volume 13, Issue 20 pp 23603—23619

Resveratrol promotes axonal regeneration after spinal cord injury through activating Wnt/β-catenin signaling pathway

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Figure 3. Resveratrol suppressed apoptosis in vivo and in vitro. (A) The apoptosis level in the tissue was detected using TUNEL staining; (B) The apoptosis level in the tissue was analyzed; (C) The expression of Bax was measured in the tissues; (D): The expression of Cleaved Caspase-3 was measured in the tissues; (E): The expression of Bcl-2 was measured in the tissues; (F): The levels of Bax, Cleaved Caspase-3, and Bcl-2 was analyzed; (G): The cell apoptosis model was established by H2O2; (H): The remarkable increased apoptosis level induced by H2O2 was suppressed by resveratrol; (I) The decreased cell proliferation ability caused by H2O2 was promoted by resveratrol. *P <0.05 compared with group SCI or H2O2. The experiments were repeated at least 3 independent times.