Research Paper Volume 13, Issue 19 pp 23376—23392

Potentiated lung adenocarcinoma (LUAD) cell growth, migration and invasion by lncRNA DARS-AS1 via miR-188-5p/ KLF12 axis

MiR-188-5p is a target gene of DARS-AS1. (A) The binding site between DARS-AS1 and miR-188-5p. (B) The dual-luciferase assay results confirmed a direct interaction between DARS-AS1 and miR-188-5p (p C) The expression level of miR-188-5p was lower than usual in LUAD tissues compared to normal tissues (p D) The expression level of miR-188-5p was lower than usual in LUAD cell lines compared to the HBE cell line (**p

Figure 5. MiR-188-5p is a target gene of DARS-AS1. (A) The binding site between DARS-AS1 and miR-188-5p. (B) The dual-luciferase assay results confirmed a direct interaction between DARS-AS1 and miR-188-5p (p < 0.05). (C) The expression level of miR-188-5p was lower than usual in LUAD tissues compared to normal tissues (p < 0.01). (D) The expression level of miR-188-5p was lower than usual in LUAD cell lines compared to the HBE cell line (**p < 0.01).