Research Paper Volume 13, Issue 19 pp 23376—23392

Potentiated lung adenocarcinoma (LUAD) cell growth, migration and invasion by lncRNA DARS-AS1 via miR-188-5p/ KLF12 axis

Overexpression of KLF12 promoted LUAD progression. (A) Three groups were transfected using miR-188-5p mimics, miR-188-5p mimics+KLF12 ov, and NC mimics in the A549 cell line. The cell proliferative capacity of the three groups was measured using the (B) CCK-8 (p C) BrdU (*p D) colony formation (p E) Overexpression of KLF12 resulted in a significant reduction in the apoptosis ratio (upper right quadrant+lower right quadrant). The transwell chamber results indicated that overexpression of KLF12 significantly promoted cell (F) migration (p G) invasion (p

Figure 8. Overexpression of KLF12 promoted LUAD progression. (A) Three groups were transfected using miR-188-5p mimics, miR-188-5p mimics+KLF12 ov, and NC mimics in the A549 cell line. The cell proliferative capacity of the three groups was measured using the (B) CCK-8 (p < 0.05), (C) BrdU (*p < 0.05), and (D) colony formation (p < 0.01) assays. (E) Overexpression of KLF12 resulted in a significant reduction in the apoptosis ratio (upper right quadrant+lower right quadrant). The transwell chamber results indicated that overexpression of KLF12 significantly promoted cell (F) migration (p < 0.01) and (G) invasion (p < 0.01), which were suppressed by miR-188-5p.