Research Paper Volume 13, Issue 20 pp 23672—23688

Differences in and verification of genetic alterations in chemotherapy and immunotherapy for metastatic melanoma

Genetic variation and relative expression differences of signature genes between chemotherapy and immunotherapy. (A and B) Mutation frequency and type of signature genes. (C) Mutations and protein domain differences of signature genes between chemotherapy group and immunotherapy group. (D) Differences in relative expression levels (log2(CPM)) of signature genes between the two groups. (E) Comparison of complete response (CR), partial response (PR) and progressive disease (PD) differences in signature genes between the two groups. *P **P ***P ****P

Figure 3. Genetic variation and relative expression differences of signature genes between chemotherapy and immunotherapy. (A and B) Mutation frequency and type of signature genes. (C) Mutations and protein domain differences of signature genes between chemotherapy group and immunotherapy group. (D) Differences in relative expression levels (log2(CPM)) of signature genes between the two groups. (E) Comparison of complete response (CR), partial response (PR) and progressive disease (PD) differences in signature genes between the two groups. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001, NS: no significance.