Research Paper Volume 13, Issue 20 pp 23726—23738

Exosome long non-coding RNA SOX2-OT contributes to ovarian cancer malignant progression by miR-181b-5p/SCD1 signaling

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Figure 7.

Exosomal SOX2-OT promotes tumor growth of ovarian cancer in vivo. (AF) The impact of exosomal SOX2-OT on tumor growth of ovarian cancer cells in vivo was analyzed by nude mice tumorigenicity assay (n = 5). The SKOV-3 cells were treated with control shRNA or SOX2-OT shRNA exosome. (A) The expression of SOX2-OT was tested by qPCR in the tumor tissues of the mice. (B) Representative images of dissected tumors from nude mice were shown. (C) The average tumor volume was calculated and presented. (D) The average tumor weight was calculated and presented. (E) The expression of miR-181b-5p was measured by qPCR in the tumor tissues of the mice. (F) The expression of SCD1 was tested by Western blot analysis in the tumor tissues of the mice. (G) The schematic model of the study. Data are presented as mean ± SD. Statistic significant differences were indicated: * P < 0.05, ** P < 0.01.