Research Paper Volume 13, Issue 20 pp 23739—23756

Loganin substantially ameliorates molecular deficits, pathologies and cognitive impairment in a mouse model of Alzheimer’s disease

A typical 2D-DIGE gel images of hippocampal proteins obtained from the 3xTg-AD mice treated with or without loganin (n = 6 for each group). (A) The merged image displaying Cy2-, Cy3-, and Cy5-labeled proteins. (B) the typical gel image of Cy2-labeled proteins. (C) the typical gel image of Cy3-labeled proteins of the 3xTg-AD mice. (D) the typical gel image of Cy5-labeled proteins of the 3xTg-AD mice treated with loganin. (E) Greyscale 2D-DIGE gel image showing the differentially expressed proteins from the hippocampus of 3xTg-AD mice treated with loganin compared to the control mice.

Figure 3. A typical 2D-DIGE gel images of hippocampal proteins obtained from the 3xTg-AD mice treated with or without loganin (n = 6 for each group). (A) The merged image displaying Cy2-, Cy3-, and Cy5-labeled proteins. (B) the typical gel image of Cy2-labeled proteins. (C) the typical gel image of Cy3-labeled proteins of the 3xTg-AD mice. (D) the typical gel image of Cy5-labeled proteins of the 3xTg-AD mice treated with loganin. (E) Greyscale 2D-DIGE gel image showing the differentially expressed proteins from the hippocampus of 3xTg-AD mice treated with loganin compared to the control mice.