Research Paper Volume 13, Issue 21 pp 24251—24270

A prognostic fibroblast-related risk signature in colorectal cancer

Analysis of TME in TCGA database and analysis of OS in high- and low-fibroblast groups. (A) In TCGA, all types of immune cells and mesenchymal cells in adjacent normal tissues are higher than that in tumor tissues. (B) We divided the 375 patients into a high-fibroblast group and a low-fibroblast group according to the median of the fibroblast content, the OS in the high-fibroblast group is shorter than in the low-fibroblast group. (C) The abundance of immune cells in the high-fibroblast group was significantly higher than that in the low-fibroblast group.

Figure 1. Analysis of TME in TCGA database and analysis of OS in high- and low-fibroblast groups. (A) In TCGA, all types of immune cells and mesenchymal cells in adjacent normal tissues are higher than that in tumor tissues. (B) We divided the 375 patients into a high-fibroblast group and a low-fibroblast group according to the median of the fibroblast content, the OS in the high-fibroblast group is shorter than in the low-fibroblast group. (C) The abundance of immune cells in the high-fibroblast group was significantly higher than that in the low-fibroblast group.