Association between NLRP3 mutations and factors in microenvironment. (A) Diverse infiltration abundance of immune cells based on NLRP3 mutational status. (B) Differential enrichment of overall stromal cells in NLRP3 mutated and wild-type patients. (C) Representation for forest plot of association between NLRP3 mutations and stromal cells enrichment. (D) Distinct distribution of activated stroma subtype in patients with and without NLRP3 mutations. (E) Multivariate Logistic regression model for the association of NLRP3 mutations with activated stroma subtype.