Research Paper Volume 13, Issue 21 pp 24271—24289

Immunological and clinical immunotherapy implications of NLRP3 mutations in melanoma

Correlation of NLRP3 mutations with ICI response rate and survival interval. (A) Distinct ICI response rate in NLRP3 mutated and wild-type patients. (B) Association of NLRP3 mutations with the response rate in multivariate Logistic regression model. (C) Kaplan-Meier survival curve of distinct NLRP3 status in ICI-treated cohort. (D) Forest plot for multivariate Cox regression model with confounders taken into account.

Figure 4. Correlation of NLRP3 mutations with ICI response rate and survival interval. (A) Distinct ICI response rate in NLRP3 mutated and wild-type patients. (B) Association of NLRP3 mutations with the response rate in multivariate Logistic regression model. (C) Kaplan-Meier survival curve of distinct NLRP3 status in ICI-treated cohort. (D) Forest plot for multivariate Cox regression model with confounders taken into account.