Priority Research Paper Volume 13, Issue 21 pp 23876—23894

Alteration of mitochondrial homeostasis is an early event in a C. elegans model of human tauopathy

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Figure 3.

Tauwt-expressing L4 nematodes display impaired mitochondrial morphology and function. (A) Representative fluorescent images of L4 transgenic nematodes expressing panneuronally mitochondria-targeted mKate2::HA. Scale Bar, 20 μm. (B) Mitochondrial population in the ventral nerve cord of L4 nematodes. Neuronal processes of tauwt-expressing L4 larvae display (C) smaller, (D, E) more circular and (F) fewer active mitochondria compared to wild type animals (n = 30–50; **P < 0.001, ***P < 0.0001; unpaired t-test).