Priority Research Paper Volume 13, Issue 21 pp 23876—23894

Figure 3. Tau^wt-expressing L4 nematodes display impaired mitochondrial morphology and function. (A) Representative fluorescent images of L4 transgenic nematodes expressing panneuronally mitochondria-targeted mKate2::HA. Scale Bar, 20 μm. (B) Mitochondrial population in the ventral nerve cord of L4 nematodes. Neuronal processes of tau^wt-expressing L4 larvae display (C) smaller, (D, E) more circular and (F) fewer active mitochondria compared to wild type animals (n = 30–50; ^**P < 0.001, ^***P < 0.0001; unpaired t-test).