Research Paper Volume 13, Issue 21 pp 24360—24378

Polymorphisms in lncRNA MIR2052HG and susceptibility to breast cancer in Chinese population

(A) Relative expression of LncRNA MIR2052HG in different genotypes of rs34841297. (B) The relative fluorescence value of different experimental groups in the dual luciferase report experiment. WT-NC: rs34841297 wild plasmids-Normal Control mimics, WT-MIMIC: rs34841297 wild plasmids-miR-4456 mimics, MUT-NC: rs34841297 mutant plasmids-Normal Control mimics, MUT-MIMIC: rs34841297 mutant plasmids-miR-4456 mimics. (C) The effect of miR-4456 combined with MIR2052HG on the proliferation of breast cancer cells (0-96h). *represents P**represents P***represents PD) Transwell experiment explores the effect of miR-4456 combined with MIR2052HG on the invasion ability of MDA-MB-231 cells. (E) Transwell experiment explores the effect of miR-4456 combined with MIR2052HG on the migration ability of MDA-MB-231 cells.

Figure 1. (A) Relative expression of LncRNA MIR2052HG in different genotypes of rs34841297. (B) The relative fluorescence value of different experimental groups in the dual luciferase report experiment. WT-NC: rs34841297 wild plasmids-Normal Control mimics, WT-MIMIC: rs34841297 wild plasmids-miR-4456 mimics, MUT-NC: rs34841297 mutant plasmids-Normal Control mimics, MUT-MIMIC: rs34841297 mutant plasmids-miR-4456 mimics. (C) The effect of miR-4456 combined with MIR2052HG on the proliferation of breast cancer cells (0-96h). *represents P<0.05; **represents P<0.01; ***represents P<0.001. (D) Transwell experiment explores the effect of miR-4456 combined with MIR2052HG on the invasion ability of MDA-MB-231 cells. (E) Transwell experiment explores the effect of miR-4456 combined with MIR2052HG on the migration ability of MDA-MB-231 cells.