Research Paper Volume 13, Issue 21 pp 24360—24378

Polymorphisms in lncRNA MIR2052HG and susceptibility to breast cancer in Chinese population

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Figure 1. (A) Relative expression of LncRNA MIR2052HG in different genotypes of rs34841297. (B) The relative fluorescence value of different experimental groups in the dual luciferase report experiment. WT-NC: rs34841297 wild plasmids-Normal Control mimics, WT-MIMIC: rs34841297 wild plasmids-miR-4456 mimics, MUT-NC: rs34841297 mutant plasmids-Normal Control mimics, MUT-MIMIC: rs34841297 mutant plasmids-miR-4456 mimics. (C) The effect of miR-4456 combined with MIR2052HG on the proliferation of breast cancer cells (0-96h). *represents P<0.05; **represents P<0.01; ***represents P<0.001. (D) Transwell experiment explores the effect of miR-4456 combined with MIR2052HG on the invasion ability of MDA-MB-231 cells. (E) Transwell experiment explores the effect of miR-4456 combined with MIR2052HG on the migration ability of MDA-MB-231 cells.