Research Paper Volume 13, Issue 21 pp 24402—24416

miR-6745-TIMP1 axis inhibits cell growth and metastasis in gastric cancer

TIMP1 promotes GC proliferation, migration and invasion. SGC-7901 and MGC-803 cells were transduced with TIMP1 expression plasmid (pTIMP1) or pcDNA3.1 as indicated. (A) Levels of TIMP1 were detected by western blot. (B) Cell proliferation was determined at the indicated time points by MTS assay. (C) Effect of TIMP1 on cell proliferative abilities was examined by EdU incorporation assay.

Figure 2a. TIMP1 promotes GC proliferation, migration and invasion. SGC-7901 and MGC-803 cells were transduced with TIMP1 expression plasmid (pTIMP1) or pcDNA3.1 as indicated. (A) Levels of TIMP1 were detected by western blot. (B) Cell proliferation was determined at the indicated time points by MTS assay. (C) Effect of TIMP1 on cell proliferative abilities was examined by EdU incorporation assay.