Research Paper Volume 13, Issue 21 pp 24402—24416

miR-6745-TIMP1 axis inhibits cell growth and metastasis in gastric cancer

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Figure 4.

miR-6745 inhibits migratory and invasive ability of GC cells. SGC-7901 and MGC-803 cells were transduced with miRNA-6745 mimic NC or miRNA-6745 mimics. (A) Levels of TIMP1 were detected by western blot. (B) MTS assay indicted that miR-6745 mimics inhibited ability of proliferation. (C) Effect of miR-6745 on cell proliferative abilities was examined by EdU incorporation assay. (D) Cell would healing ability was impaired in miRNA-6745 mimics cells. (E) Chamber invasion ability was damaged in miRNA-6745 mimics cells. (F) The expression levels of Ki67 were detected by immunofluorescence. Data represent the means ± SEM. **P < 0.01.