Research Paper Volume 13, Issue 21 pp 24402—24416

miR-6745-TIMP1 axis inhibits cell growth and metastasis in gastric cancer

Schematic diagram of roles of miR-6745-TIMP1 axis on Wnt/β-catenin signaling and its function in gastric tumorigenesis. Under normal non-transformed conditions, miR-6745 binds to the 3-UTR in the TIMP1 mRNA and down-regulates TIMP1 protein levels. In GC, there is reduced levels of miR-6745 leading to elevated TIMP1 expression and activation of the Wnt/β-catenin signaling pathway.

Figure 7. Schematic diagram of roles of miR-6745-TIMP1 axis on Wnt/β-catenin signaling and its function in gastric tumorigenesis. Under normal non-transformed conditions, miR-6745 binds to the 3-UTR in the TIMP1 mRNA and down-regulates TIMP1 protein levels. In GC, there is reduced levels of miR-6745 leading to elevated TIMP1 expression and activation of the Wnt/β-catenin signaling pathway.