Research Paper Volume 13, Issue 23 pp 25518—25549

Identification of a novel immune signature for optimizing prognosis and treatment prediction in colorectal cancer


Figure 4. The immune landscape of two distinctive subclasses in the training cohort. (A) The differential expression level of immune checkpoint molecules between two subclasses with statistical significance. (B) Violin plots of the CD4, CD8A, CD47, CTLA4, LAG3, MAGE-A3, PD-1 and PD-L1 expression levels for two subtypes. (C) The association between risk score and CD47 as well as PD-1 expression levels. (D) Immune infiltration between high- and low- risk subtypes with statistical significance in the training cohort. (E) Correlation analysis between the expression of seven IRGs and the infiltration of immune cells. Statistical significance at the level of ns ≥ 0.05, * < 0.05, ** < 0.01 and *** < 0.001.