Research Paper Volume 13, Issue 23 pp 25564—25577

CHIP ameliorates cerebral ischemia-reperfusion injury by attenuating necroptosis and inflammation


Figure 2. CHIP overexpression in CHIP KI mice. (A, B) Western blot and quantitative analysis of CHIP in the cortex, striatum, and hippocampus. (C) The mRNA expression of CHIP. (D) Immunostaining of CHIP, NeuN, and DAPI in the cortex and hippocampus of WT mice and CHIP KI mice. (E) Quantitative analysis of immunostaining showed the positive numbers of CHIP. WT, WT mice; KI, CHIP KI mice. Scale bar =100 μm. Data are presented as the mean ± SEM; n=6/group; *P < 0.05.