Coupling of serum CK20 and hyper-methylated <i>CLIP4</i> as promising biomarker for colorectal cancer diagnosis: from bioinformatics screening to clinical validation

Zhongjian Liu; Hui Tang; Wen Zhang; Jinli Wang; Lilan Wan; Xisha Li; Yuping Ji; Na Kong; Yanfang Zhang; Jiangang Wang; Zhang Fan; Qiang Guo

doi:doi:10.18632/aging.203804

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Research Paper Volume 13, Issue 24 pp 26161—26179

Coupling of serum CK20 and hyper-methylated CLIP4 as promising biomarker for colorectal cancer diagnosis: from bioinformatics screening to clinical validation

Figure 2. The expression of CEA, CK18 and CK20 in tumor tissues and cancer cell lines. The mRNA expression of CEA (A), CK18 (B) and CK20 (C) in certain tumor tissues and CRC tissues was analyzed by GEPIA. The protein expression of CEA (A), CK18 (B) and CK20 (C) in CRC tissues was stained by immunohistochemistry (IHC) and analyzed by HPA. The mRNA expression of CEA (A), CK18 (B) and CK20 (C) in cancer cell lines was analyzed by CCLE. Abbreviations: COAD: colon adenocarcinoma; READ: rectum adenocarcinoma.