Research Paper Volume 14, Issue 1 pp 443—461

PEGylation and antioxidant effects of a human glutathione peroxidase 1 mutant

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Figure 9. Effects of GPx1M and SS-mPEG-GPx1M on MDA (A) and LDH release (B) from H9c2 cells incubated with ADR. Cells were either preincubated with GPx1M/SS-mPEG-GPx1M (0.08 U/mL) for 1 h and then co-incubated with 2.5 μM ADR for 24 h or incubated with 2.5 μM ADR for 12 h and then co-incubated with GPx1M/SS-mPEG-GPx1M (0.08 U/mL) for another 12 h. $$p < 0.01 and $$$p < 0.001 vs. the control group, #p < 0.05 and ##p < 0.01 vs. the ADR group.