Figure 4. PKC and Ras cooperate to promote Cr(VI)-mediated drug resistance and long-term survival. (A) Cells with or without chronic Cr(VI) exposure were received different treatments. Subsequently, the percentages of the cells with fragmented DNAs were measured. The error bars were SD (n = 5, p < 0.01). (B) After the same treatments as described above, the cells were subjected to Annexin V apoptotic assay. The error bars were SD (n = 5, p < 0.01). (C) After the treatments described above, colony formation assay was conducted. The plating efficiencies were measured (right panel) and colonies were imaged (right panels). The error bars were SD (n = 5, p < 0.05).