Research Paper Volume 14, Issue 6 pp 2678—2694
piRNA-6426 increases DNMT3B-mediated SOAT1 methylation and improves heart failure
Figure 9. Schematic of regulation of heart failure by piRNA-6426-mediated methylation of the SOAT1. piRNA-6426 regulates the methylation level of SOAT1 by recruiting DNMT3B to the promoter of SOAT1, thereby inhibiting cardiomyocytes apoptosis, inflammation and oxidative stress.