Research Paper Volume 14, Issue 6 pp 2805—2818

Figure 3. ROC curve analysis of the mean DTI and NODDI values for altered brain regions. (A) The area under the ROC curve were 0.976, (p < 0.0001; 95% CI: 0.941–1.000) for left superior longitudinal fasciculus (FA); body of corpus callosum (FA) 0.960, (p < 0.0001; 95% CI: 0.908–1.000). (B) The area under the ROC curve were 0.994 (p < 0.0001; 95% CI: 0.979–1.000) for left superior longitudinal fasciculus (MD); right posterior limb of internal capsule (MD) 0.891, (p < 0.0001; 95% CI: 0.804–0.979); right posterior thalamic radiation (MD) 0.918, (p < 0.0001; 95% CI: 0.841–0.994); genu of corpus callosum (AD) 0.888, (p < 0.0001; 95% CI: 0.794–0.982); right posterior limb of internal capsule (AD) 0.880, (p < 0.0001; 95% CI: 0.784–0.976); right splenium of corpus callosum (AD) 0.900, (p < 0.0001; 95% CI: 0.816–0.984). (C) The area under the ROC curve were 0.941, (p < 0.0001; 95% CI: 0.879–1.000) for left anterior corona radiata; body of corpus callosum 0.867, (p < 0.0001; 95% CI: 0.765–0.969); left superior longitudinal fasciculus (ODI) 0.874, (p < 0.0001; 95% CI: 0.780–0.967); right splenium of corpus callosum 0.968, (p < 0.0001; 95% CI: 0.916–1.000); left posterior corona radiata 0.971, (p < 0.0001; 95% CI: 0.934–1.000). (D) The area under the ROC curve were 0.880 (p < 0.0001; 95% CI: 0.790–0.970) for left superior longitudinal fasciculus (FICVF). Abbreviations: FA: fractional anisotropy; MD: mean diffusivity; AD: axial diffusivity; RD: radial diffusivity; ODI: orientation dispersion index; FISO: isotropic volume fraction; FICVF: intra-cellular volume fraction; AUC: area under the curve; ROC: receiver operating characteristic.