Priority Research Paper Volume 14, Issue 10 pp 4195—4210
Long-term treatment with chloroquine increases lifespan in middle-aged male mice possibly via autophagy modulation, proteasome inhibition and glycogen metabolism
Figure 1. Treatment with chloroquine expanded the median and maximum lifespan in middle-aged male NMRI mice. Macroscopically, the fur of the treated animals looked less ruffled as compared to controls (A vs. B). The male mice fed with CQ significantly lived longer (786 days) than controls (689 days) and the median lifespan was also significantly different between the two groups (C). Long-term treatment with CQ (50 mg/kg) led to a gradual increase in the body weight of control animals that peaked at day 600 (t-test, two-tailed) (D). The volume of liquid intake was, on the average, significantly lower in the CQ-treated group (t-test, two-tailed) (E). However, the average amount of consumed food was not significantly different (F). Data are mean ± SD values. N = 28 for each group.