Combined impacts of histamine receptor H1 gene polymorphisms and an environmental carcinogen on the susceptibility to and progression of oral squamous cell carcinoma

Yi-Fang Ding; Yung-Wei Lin; Wen-Kuan Chiu; Chiao-Wen Lin; Yi-Chieh Yang; Lun-Ching Chang; Jungshan Chang; Shun-Fa Yang; Ming-Hsien Chien

doi:doi:10.18632/aging.204089

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Research Paper Volume 14, Issue 10 pp 4500—4512

Combined impacts of histamine receptor H1 gene polymorphisms and an environmental carcinogen on the susceptibility to and progression of oral squamous cell carcinoma

Figure 1. Clinical relevance of histamine receptor H1 (HRH1) levels in head and neck squamous cell carcinoma (HNSCC) or oral squamous cell carcinoma (OSCC) patients obtained from TCGA and GEO databases. (A, B) HRH1 expression was higher in HNSCC tissues (A) and OSCC tissues (B) than in normal tissues (database sources: TCGA and GSE78060). (C) HRH1 expression levels in OSCC from GSE78060 were compared according to the tumor size (T stages). (D) Kaplan-Meier curves for overall and disease-specific survival (left panel) and recurrence-free survival (right panel) of patients with HNSCC and OSCC, as categorized according to high or low expression of HRH1. The p value indicates a comparison between patients with HRH1^high and HRH1^low. (database sources: TCGA and GSE31056).