Research Paper Volume 14, Issue 12 pp 5075—5085
The minor allele of rs17427875 in long non-coding RNA-HOXA11-AS influences the prognosis of subarachnoid hemorrhage (SAH) via modulating miR-15a and STAT3 expression
Figure 3. Sequence analysis showed that miR-15a could potentially target lncRNA-HOXA11-AS (A), and the transfection of miR-15a suppressed the luciferase activity of wild-type lncRNA-HOXA11-AS (B) in THP-1 cells. Moreover, sequence analysis showed that miR-15a could potentially target the 3’UTR STAT3 (C), and the transfection of miR-15a suppressed the luciferase activity of wild-type STAT3 (D) in THP-1 cells. Meanwhile, the transfection of miR-15a mimics significantly repressed the relative expression of HOXA11-AS (E), STAT3 mRNA (F) and protein (G) (*P value < 0.05 vs. control; **P value < 0.05 vs. NC group).