Research Paper Volume 14, Issue 12 pp 5097—5115
Calreticulin nuclear translocalization alleviates CaM/CaMKII/CREB signaling pathway to enhance chemosensitivity in HDAC inhibitor-resistant hepatocellular carcinoma cells
Figure 4. HDAC inhibitors trigger CRT translocation to the nucleus in liver cancer cells overexpressing CRT. (A, B) HDAC inhibitors activate CRT nuclear translocation and inhibit CaM/CaMKII/CREB signaling pathway in the nuclear isolate of the HA22T parental cells. (C, D) HDAC inhibitors activate CRT nuclear translocation and inhibit CaM/CaMKII/CREB signaling pathway in the nuclear isolate of HCC cells overexpressing CRT.