Research Paper Volume 14, Issue 12 pp 5097—5115
Calreticulin nuclear translocalization alleviates CaM/CaMKII/CREB signaling pathway to enhance chemosensitivity in HDAC inhibitor-resistant hepatocellular carcinoma cells
Figure 5. Mechanism of CRT-mediated chemosensitivity in HCC cells via nucleus translocation and reduction in CaM/CaMKII/CREB signaling. We revealed that decreased expression of CRT lead to down-regulated the chemosensitivity of HDACi in HCC cells. Moreover, we also obtain that CRT translocation into the nucleus is an important mechanism of chemoresistance and HDACi-induced cell apoptosis in HCC cells.