Research Paper Volume 14, Issue 16 pp 6689—6715
Prognostic alternative splicing events related splicing factors define the tumor microenvironment and pharmacogenomic landscape in lung adenocarcinoma
Figure 4. Genetic alteration landscape of 16 splicing factors (SFs) in LUAD. (A) Differential mRNA expression of 16 SFs between normal and tumor samples (*P < 0.05; **P < 0.01; ***P < 0.001). (B) CNV mutation was widespread in 16 SFs. The column represented the alteration frequency. Deletion, green dot; Amplification, pink dot. (C) 56 of the 561 LUAD patients showed genetic alterations of 16 SFs. (D) The location of CNV alterations of 16 SFs on chromosomes. (E) The relationship between SFs in LUAD. The thickness of lines linking SFs showed the correlation strength. Negative correlation, blue; positive correlation, pink. Up-regulated SFs, red; down-regulated SFs, orange; no sense of SFs in differential expression, grey.