Research Paper Volume 14, Issue 19 pp 7794—7823
Multifaceted investigation underlies diverse mechanisms contributing to the downregulation of Hedgehog pathway-associated genes INTU and IFT88 in lung adenocarcinoma and uterine corpus endometrial carcinoma
Figure 2. The Hh pathway-associated genes were enriched in LUAD and UCEC tumor samples. (A) The expression of INTU was significantly downregulated in LUAD and UCEC tumor samples. * denotes p < 0.05. (B) The GO and Reactome enrichment analysis on the top 100 genes that showed similar expression pattern as INTU from LUAD tumor samples. BP indicates biological process, and CC indicates cellular compartment. (C) The GO and Reactome enrichment analysis on the top 100 genes that showed similar expression pattern as INTU from UCEC tumor samples. (D) Construction of the PPI network using genes that showed similar expression pattern as INTU in LUAD tumor samples. Two enriched Reactome pathways “Anchoring of the basal body to the plasma membrane” and “Hedgehog ‘off’ state” were highlighted. (E) Construction of the PPI network using genes that showed similar expression pattern as INTU in UCEC tumor samples. Three enriched Reactome pathways “Anchoring of the basal body to the plasma membrane”, “Hedgehog ‘off’ state” and “Intraflagellar transport” were highlighted.