Research Paper Volume 15, Issue 1 pp 53—69

Figure 7. miR-6742-5p was involved in regulating the invasion and migration of LUAD via targeting FGF8/ERK1/2/MMP9/MMP2. (A) The expression of FGF8, ERK1/2, MMP9 and MMP2 was evaluated by western blot in cells treated with and without RO 67-7476 cells. (B) The expression of FGF8, ERK1/2, MMP9 and MMP2 quantification in cells treated with and without RO 67-7476 cells. ** P < 0.01. Relative protein levels of FGF8 (-)**P=0.0009miR-6742-5p OE group vs NC group;**P=0.0028miR-6742-5p KD group vs NC group; Ro 67-7476 **P=0.004miR-6742-5p OE group vs NC group;**P=0.0065miR-6742-5p KD group vs NC group; Relative protein levels of ERK1/2 *P=0.0134miR-6742-5p OE group vs NC group;**P=0.0063miR-6742-5p KD group vs NC group; Relative protein levels of MMP2 **P=0.0066miR-6742-5p OE group vs NC group;**P=0.0017miR-6742-5p KD group vs NC group; Relative protein levels of MMP9 **P=0.0058miR-6742-5p OE group vs NC group;**P=0.0051miR-6742-5p KD group vs NC group.