Research Perspective Volume 14, Issue 20 pp 8140—8149
Rapamycin treatment early in life reprograms aging: hyperfunction theory and clinical practice
Figure 1. Critical time window for reprograming of aging by inhibiting developmental growth. (A) Treatment with rapamycin immediately after birth extended lifespan of normal mice. (B) Treatment with GH immediately after birth shortened lifespan of GH-deficient mice. GH-deficient mice have low activity of mTORC1. A and B are mirror images showing the same phenomenon.