Research Paper Volume 14, Issue 23 pp 9445—9457

Ganglioside GD1a enhances osteogenesis by activating ERK1/2 in mesenchymal stem cells of Lmna mutant mice

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Figure 6. Analysis of trabecular and cortical bone of the femur. LmnaDhe/+ mutant mice were intraperitoneally injected with ganglioside GD1a at 5, 10, and 30 mg/kg/2-day for 7 weeks. (A) The mice were weighed once a week for 7 weeks, and (B) Hematoxylin and eosin staining of the femur nearby the metaphysic area. (C) Micro-CT analysis of trabecular and cortical bone of femur. (D) Representative parameters of trabecular and cortical bone, respectively. *p < 0.05 indicates a significant difference the normal; **p < 0.01 indicates a significant difference the Normal; #p < 0.05 indicates a significant difference the LmnaDhe/+ mutant mouse.