Research Paper Volume 14, Issue 23 pp 9466—9483

Identification of natural products and FDA-approved drugs for targeting cancer stem cell (CSC) propagation

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Figure 7. Testing the efficacy of two forms of vitamin B3 on CSC propagation. (A) Nicotinamide, also known as niacinamide, significantly increases CSC propagation by >1.5-fold, at concentrations of 10 and 20 μM. (B) However, Nicotinic acid (or niacin) does not have any effect on mammosphere formation. Bar graphs are shown as the mean ± SEM; t-test, two-tailed test. ****p < 0.0001. Chemical formulae are indicated.