Research Paper Volume 14, Issue 23 pp 9484—9549

DNA methylation GrimAge version 2

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Figure 3. Meta analysis forest plots for predicting all-cause mortality in all, smokers and non-smokers. Fixed effect models meta analysis was performed to combine mortality analysis across 15 strata from 9 study cohorts. Analysis was performed across different strata formed by racial groups within cohort and set within LBC36, using (A, B) all individuals, (C, D) smokers (former and current), and (E, F) non-smokers, respectively. Each panel reports a meta-analysis forest plot for combining hazard ratios predicting time-to-death based on AgeAccelGrim2 (on the left panel) and AgeAccelGrim (on the right panel). The sub-title of each panel reports the meta analysis P-value. Each hazard ratio (HR) corresponds to a one-year increase in AgeAccel measure.