Research Paper Volume 15, Issue 1 pp 70—91
Histone methyltransferase Smyd2 drives vascular aging by its enhancer-dependent activity
Figure 8. Ang II-induced Smyd2 upregulation activates enhancers adjacent to Cdkn2a (p16) and Cdkn1a (p21) genes by enhancing H3K4me1 enrichments and further promotes genes transcription, resulting in senescence-associated phenotypes and the development of vascular aging-related diseases.