Research Paper Volume 15, Issue 5 pp 1445—1474
Identification of GNG7 as a novel biomarker and potential therapeutic target for gastric cancer via bioinformatic analysis and in vitro experiments
Figure 11. Overexpression of GNG7 inhibited the proliferation and clone-formation abilities and induced cell cycle arrest and apoptosis in GC cells. (A) GNG7 mRNA levels in GC cell lines (AGS, BGC823, HGC27 and SGC7901) compared to the normal epithelial cell line GES-1. (B) GNG7 mRNA levels in control and GNG7-overexpressing SGC7901 cells. (C, D) Proliferation and colony formation abilities of control and GNG7-overexpressing SGC7901 cells. (E) Cell cycle distribution in control and GNG7-overexpressing SGC7901 cells. (F) Cell apoptosis rate in control and GNG7-overexpressing SGC7901 cells. GC, gastric cancer. **P < 0.01 and ***P < 0.001 versus control or blank group; ##P < 0.01 and ###P < 0.001 versus pcDNA3.1 group.