Research Paper Volume 15, Issue 6 pp 1931—1943
Exosomal miR-370-3p increases the permeability of blood-brain barrier in ischemia/reperfusion stroke of brain by targeting MPK1
Figure 6. miR-370-3p aggravated I/R-Induced BBB disruption by targeting MAPK1. (A) qPCR demonstrating that miR-370-3p regulates MAPK1 expression. (B) Transendothelial electrical resistance assessments was implemented to analyze BBB disruption. (C, D) Cellular proliferation following miR-370-3p mimic transfection and/or MAPK1 overexpression was assessed via infarct volume and BBB permeability in brain tissues of cerebral I/R rats. ** p<0.01, *** p<0.005, **** p<0.001.