Research Paper Volume 15, Issue 6 pp 1977—2004
Hsp22 pretreatment protects against LPS-induced hippocampal injury by alleviating neuroinflammation and apoptosis by regulating the NLRP3/Caspase1/IL-1β signaling pathway in mice
Figure 8. Hsp22 overexpression pretreatment alleviates Iba1 activation induced by LPS. (A, B) Immunohistochemical staining images of Iba1(***p < 0.005 vs. Control; ns: p > 0.05, LPS vs. LPS+Lv-Hsp22-NC; ###p < 0.005 vs. LPS+Lv-Hsp22-NC). The arrow points to Iba1 positive cell. (C) The protein band of Iba1 and its expression in Hippocampus tissue (**p < 0.01 vs. Control; ns: p > 0.05, LPS vs. LPS+Lv-Hsp22-NC; #p < 0.05 vs. LPS+Lv-Hsp22-NC). (D) The protein band of Iba1 and its expression in BV2 Microglial Cells. (***p < 0.005 vs. Control; ns: p > 0.05, LPS vs. LPS+OE-Control; #p < 0.05 vs. LPS+OE-Control).