Research Paper Volume 15, Issue 9 pp 3331—3355
In vitro and in vivo effects of zoledronic acid on senescence and senescence-associated secretory phenotype markers
Figure 2. Zoledronic acid reduces circulating SASP markers and improves grip strength in old mice. (A) Zoledronic acid significantly reduces a panel of SASP markers in old mice (overall p-value is using the harmonic mean approach (see Methods)); (B) changes in serum CCL7, IL1β, TNFRSF1A, and TGFβ1 in the vehicle- vs. zoledronic acid- treated mice; effects of zoledronic acid on (C) grip strength; (D) hang endurance; and (E) treadmill endurance. (F–H) show these parameters normalized to body weight. p-values are using the Mann-Whitney test; n = 15 Veh, n=14 Zol mice/group (A, B) and n=15 per group (C–H).