Research Paper Volume 15, Issue 10 pp 3984—4011

Stress granules sequester Alzheimer’s disease-associated gene transcripts and regulate disease-related neuronal proteostasis

class="figure-viewer-img"

Figure 5. Distinct distribution of the physical basis for AD-associated RNAs after stress. (AJ) Boxplots depicting total transcript length (A and G), CDS length (B), 5′UTR length (C), 3′UTR length (D), GC content (E and H), and abundance (F and I) of mRNAs (AF) and lncRNAs (GI), respectively, for each of AD-associated RNAs (AD) and other RNAs (non-AD). Statistical significances were assessed by Wilcoxon rank sum test. ns: not significant, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001. (J, K) Pie chart depicting the relative contribution of each class of RNA (SG-enriched, SG-depleted, or “Neither”) for mRNAs (J) and lncRNAs (K), respectively. (LT) Boxplots depicting total transcript length (L and R), CDS length (M), 5′UTR length (N), 3′UTR length (O), GC content (P and S), and abundance (Q and T) of mRNAs (LQ) and lncRNAs (RT), respectively, for each of AD-associated RNAs (AD) and other RNAs (non-AD).