Research Paper Volume 15, Issue 13 pp 6225—6254

Figure 2. Novel molecular classification based on FARGs in TCGA cohort. (A) The intersection of 199 FARGs between TCGA, CGGA, and GSE16011 cohorts. (B–D) Consensus clustering matrix based on 192 FARGs for k=2, k=3, and k=4. (E) The optimal number of consensus clustering matrices is determined by the cumulative distribution function of the unsupervised consensus clustering algorithm. (F) Obvious differences in the transcriptomes between FARG1 and FARG2 subtypes were analyzed by principal component analysis (PCA). (G, H) K-M survival curves of glioma patients. (I) The distributions of five clinicopathological characteristics and 199 FARGs between FARG1 and FARG2 subtypes. (J) GSVA between FARG1 and FARG2 subtypes. Red and blue represent the relative activation and inhibition of the pathways, respectively. *P<0.05, **P<0.01, ***P<0.001.