Research Paper Volume 15, Issue 15 pp 7362—7380

Figure 4. Comparative KEGG and Reactome pathway enrichment analysis between Ovx/Sham and OA/YA. Significant and differentially regulated phosphopeptides (adjusted p-value < 0.05 and |FC| ≥ 1.4) were mapped back to their precursor protein and the list was submitted to R for analysis of KEGG and Reactome pathways. The top 10 overrepresented (A) KEGG and (B) Reactome pathways were clustered using K-means clustering. The size of the circle represents the number of proteins associated to the pathway, and the connecting lines represents the strength of the similarity (i.e., shorter and thicker lines correspond to stronger similarity and inversely.