Research Paper Volume 15, Issue 18 pp 9438—9452

Astragalus polysaccharide inhibits the development of urothelial carcinoma by activating AMPK signaling to induce BENC1-xCT complex formation


Figure 7. APS inhibited the growth of tumors in nude mice. (A) Representative images of tumor tissues from nude mice. APS significantly inhibited tumor volume (B) and weight (C) in nude mice. APS increased the levels of Fe2+ (D) and MDA (E) in tumor tissues. (F) APS decreased GSH levels in tumor tissues. The RT-PCR results showed that APS increased the mRNA levels of ptgs2 (G) and Chac1 (H) in tumor tissues. (I) After APS treatment, the phosphorylation levels of AMPK and BECN1 were increased in the tumor tissues of nude mice. *p < 0.05, **p < 0.01, ***p < 0.001 vs. Con.