Research Paper Volume 15, Issue 22 pp 12723—12737

Figure 2. Effects of Tat-HSP10 and HSP10 on novel object recognition (A) and Morris water maze task (B) in adult and aged mice. (A) Exploratory preference (familiar vs. new object), total exploration time, number of contacts with a novel object during the testing trial, and distance moved were analyzed in control, HSP10-, and Tat-HSP10-treated groups of adult and aged mice. (B) Escape latency was analyzed in four consecutive navigation tests. The time consumed in the aim quadrant, swimming speed, and platform crossing times were measured on the next navigation test in the control, HSP10-, and Tat-HSP10-treated groups of adult and aged mice. Data are represented as the mean ± SD (n = 10 each group; analyzed by one-way or two-way ANOVA tests followed by Tukey’s post hoc test, ^*P < 0.05, vs. the familiar object; ^aP < 0.05, vs. adult group; ^bP < 0.05, vs. control group; ^cP < 0.05, vs. HSP10-treated group). Abbreviations: HSP: Heat shock protein; ANOVA: Analysis of Variance; SD: standard deviation.