Research Paper Volume 15, Issue 22 pp 13486—13503

Figure 3. The dependency of leukemia cells on GPX4 (A) and AIFM2 (B). The blue circle represents the SHI-1 AML cell line with nonconserved gene mutations. A score < 0 means that the selected cell line is more likely to be dependent on the gene. A score = 0 is equivalent to a gene that is not essential, whereas a score of -1 corresponds to the median of all common essential genes.