Research Paper Volume 15, Issue 23 pp 13854—13864
Long noncoding RNA MEG8 induces an imbalance of Th17/Treg cells through the miR-107/STAT3 axis in Henoch-Schonlein purpura rats
Figure 6. MEG8 overexpression rescued the dysregulated Th17/Treg ratio by thwarting miR-107 within HSP CD4+ T-cell populations. (A, C) miR-107 and STAT3 expression and (B, D) STAT3 protein level, (E–G) analysis of Th17 and Treg cellular populations, and (H) Th17/Treg cell ratio within HSP CD4+ T cellular populations simultaneously transfected with the mimic NC/miR-107 mimic and empty vector/MEG8 overexpression vector. *P <0.01 vs. Control group; #P <0.01 vs. Vector + mimic NC group; ※P < 0.01 vs. MEG8 + mimic NC group.