Crosstalk between copper homeostasis and cuproptosis reveals a lncRNA signature to prognosis prediction, immunotherapy personalization, and agent selection for patients with lung adenocarcinoma

Chao Ma; Zhuoyu Gu; Weizheng Ding; Feng Li; Yang Yang

doi:doi:10.18632/aging.205281

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Research Paper Volume 15, Issue 22 pp 13504—13541

Crosstalk between copper homeostasis and cuproptosis reveals a lncRNA signature to prognosis prediction, immunotherapy personalization, and agent selection for patients with lung adenocarcinoma

Figure 1. Flowchart of the main steps, design, and analysis process of this study [80]. Abbreviations: TCGA: The Cancer Genome Atlas; LUAD: lung adenocarcinoma; CoCuLncSig: copper homeostasis and cuproptosis regulated lncRNA signature; HR: hazard ratio; ROC: receiver operating characteristic; AUC: area under the ROC curve; TP: true positive rate; FP: false positive rate; PC: principal component; GSEA: gene set enrichment analysis; CMap: Connectivity Map; DEGs: differentially expressed genes; qRT-PCR: quantitative real-time PCR.