Research Paper Volume 15, Issue 23 pp 14263—14291

Figure 4. Functional characterization of phosphorylated proteins and construction of the kinase-substrate regulatory network. (A) Correlation between protein expression and its phosphorylation intensity. (B) Changes in the intensity of phosphosites between LUAD and non-tumor samples. (C) Functional enrichment analysis of phosphorylated proteins with differential phosphorylation. (D) Significantly enriched kinase motifs for phosphosites that are dysregulated in LUAD. (E) Kinase annotation and family analysis for dysregulated phosphosites. (F) A phosphorylation regulatory network constructed based on dysregulated phosphosites and annotated kinase-substrate relationship pairs in LUAD.