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Research Paper Volume 15, Issue 23 pp 14323—14332

Specific knockout of notch-1 attenuates non-alcoholic fatty liver disease by promoting SHP2 phosphorylation

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Figure 3. Notch-1MAC-KO regulates the expression of oxidative stress-related factors and related proteins in macrophages of HFD-induced NAFLD mice. (A) Protein band plots of NOX2, NOX4, p-PI3K and p-SHP2 in macrophages. (B) Relative protein expression of NOX2, NOX4, p-PI3K and p-SHP2 in macrophages. (**p < 0.01, *p < 0.05, ns: p > 0.05; N = 6).