Research Paper Volume 16, Issue 9 pp 8348—8360

ANGPTL4, a direct target of hsa-miR-133a-3p, accelerates lung adenocarcinoma lipid metabolism, proliferation and invasion


Figure 3. The effect of ANGPTL4 on LUAD cell growth in vivo. (A) The effects of ANGPTL4 shRNA lentivirus plasmid transfection or empty vector lentivirus plasmid transfection on A549 growth in vivo. The tumor weight (B) and volume (C) of the xenografts in ANGPTL4 KD group and vector group. (D) IHC staining for E-cadherin, N-cadherin, PCNA and ANGPTL4 in these xenografts for confirming the effects of ANGPTL4 on LUAD EMT cascade and proliferation. *P < 0.05 indicates statistical significance compared with the control.