Research Paper Volume 15, Issue 22 pp 13558—13578
Lnc-PTCHD4-AS inhibits gastric cancer through MSH2-MSH6 dimerization and ATM-p53-p21 activation
Figure 4. PTCHD4-AS suppressed GC proliferation via MSH2-MSH6 dimer. (A) Western blotting analysis of MSH2 and MSH6 protein levels in SGC7901 and MGC803 cells stably overexpressing EV or PTCHD4-AS after transduction with siCtrl or siMSH2 for 48 h. (B) Cell proliferation assays after transduction with siCtrl or siMSH2 for 72 h. (C, D) Cell cycle analysis after transduction with siCtrl or siMSH2 for 48 h. Data are presented as mean ± SD, * P < 0.05, ** P < 0.01, *** P < 0.001.